The replacement of a diseased liver with a healthy liver is known as liver transplantation. Liver transplantation is used as a treatment option for acute liver failure and end-stage liver disease. Orthotopic transplantation is a common and effective technique used for liver transplantation. The transplantation surgery usually takes 4 to 18 hours. The common requirements for a liver donor include good health, a blood type which is compatible with the recipient, having an age of 20-60 years, and being of similar or larger size than the recipient. Liver transplantation involves a few complications, such as infection, bleeding, possibility of blood clots, painful incision and prolonged recovery. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of liver transplantation. It studies, analyzes and upholds the pillars of liver transplantation and its utmost significance in modern times. The extensive content of this book provides the readers with a thorough understanding of the subject.