This book includes research by internationally renowned experts. They discuss the comparative usefulness of their work in relation to diabetic nephropathy. The book elucidates the new role of oxidative stress in the development of diabetic nephropathy and intrarenal renin-angiotensin-aldosterone system (RAAS) and presents the latest pharmacological interventions in the treatment of diabetic nephropathy. It highlights other significant contributions outside of the RAAS in the pathogenesis of diabetic nephropathy including epithelial-mesenchymal-transition (EMT), immune cytokines and AGE/RAGE and also presents latest information on several pathophysiological determinants in the development of diabetic nephropathy. Lastly, recent information on numerous distinct pharmacological interventions of diabetic nephropathy is also included.