A descriptive account based on the field of health risk assessment has been presented in this elaborative book. It consists of a compilation of various health risk assessments for existing and rising hazards spanning a continuum. Psychoactive drug usage in drivers of delivery trucks and using look-back risk evaluation for accidental syringe re-use in healthcare settings are some of the case studies on existing risks covered in this book. Case studies regarding rising risks include precautionary actions to protect blood supplies; deposition of nanoparticles in the lung; and the epistemic issues related to genetically enhanced organism risk evaluations. The book also highlights progressing health risk assessment analysis through a post-genomics lens and elucidates the case studies on personalized genomics, advancing in silico models for risk evaluation and novel data analyses.