Retinoblastoma is described as a rare malignant tumor of the retina, generally affecting young children. The first gene discovered to have the capability of curbing tumor was Retinoblastoma. This breakthrough led to the rise of a new opportunity in the sphere of oncology, resulting in the detection of 35 tumor suppressor genes in the human genome. This text is an extensive collection of basic and advanced data which can cater to budding clinicians and experts simultaneously. Substantial amount of information on latest progress and state-of-the-art knowledge in intracellular molecular cross-talking of retinoblastoma protein with various cellular viral-like proteins has also been provided in this book.