This book presents the proceedings of TE2022, the 29th ISTE International Conference on Transdisciplinary Engineering, held at the Massachusetts Institute of Technology in Cambridge, United States, from 5 – 8 July 2022. Transdisciplinary engineering is the exchange of knowledge in the context of an innovation, in product, process, organisation or social environment. ISTE aims to explore and promote the evolution of engineering to incorporate transdisciplinary practices in which the exchange of different types of knowledge from a diverse range of disciplines is fundamental. The theme for the TE2022 conference is the future of engineering, and the 75 papers included here, which have all undergone a rigorous peer-review process, cover a wide range of topics and are grouped under 10 headings: Requirements, Knowledge and Architecture in Engineering; Case Studies; Energy, Environment, and Sustainability; Engineering Teamwork; Digital Engineering; imulation, Optimization, and Analytics; Manufacturing; Policy, Decisions, and Innovation; Engineering Education; Research on TE. The book will be of interest to all those working in the field of engineering today.