Title page -- Contents -- Preface -- Vorwort -- Summary -- Zusammenfassung -- Clinical Knowledge Management to Support Evidence-Based Medicine -- The PROforma Guideline Specification Language: Progress and Prospects -- Specification, Execution and Management of Clinical Test Ordering Protocols: A Database Approach -- PIERCE Program: Informatics Support for Multi-Site Clinical Research: An Environment for Consensual Use of Clinical Protocols and Clinical Trials -- Is Workflow Management Appropriate for Therapy Planning? -- Developing a Knowledge-Based Tool for Authoring Clinical Trial Protocols -- An Experiment in Sharing and Reusing OncoDoc's Breast Cancer Guideline Knowledge -- Guide-X - A Step-by-Step, Markup-Based Approach to Guideline Formalisation -- Representation Formalisms and Computational Methods for Modeling Guideline-Based Patient Care -- Automating Dynamic Decision Model Construction to Support Clinical Practice Guideline Development -- Author Index