This book presents the proceedings of HealthGrid 2010, the latest in the annual open forum for the integration of grid technologies, e science and e health methods and their application in biomedicine and healthcare. Previous conferences have highlighted the need to involve all actors, such as physicians, scientists and technologists, and have served to demonstrate the usefulness of grids to potential application domains, at least at the prototype level. More recently, cloud computing seems set to make an impact as a paradigm more readily acceptable in the practice of healthcare informatics, w.