In order to achieve and maintain cross-border interoperability of electronic health records systems, it is necessary to manage the continuous process of change and adaptation of many elements within and across electronic infrastructures in neighboring countries. This volume presents the proceedings of the 11th EFMI special topic conference entitled "e-Health across Borders without Boundaries", held in Lasko, Slovenia, in April 2011. Both the conference and the contents of this book highlight health-related communication and collaboration at regional, national and international level