Today, nurses must be able to transfer their knowledge to new situations, and stay current with new disorders, treatments, and evidence-based practice. Nursing: A Concept–Based Approach to Learning, Volume I, Second Edition will help them achieve all these goals. Its concept-based approach requires students to participate actively, assume more responsibility for their knowledge, integrate concepts, apply information, and use clinical reasoning. Instead of memorizing thousands of alterations, students gain in-depth knowledge of selected alterations, and learn how to apply that knowledge as new challenges and client presentations come their way. The first of three volumes, this fully-updated Volume I focuses on 21 crucial biophysical concepts: acid-base balance; cellular regulation; comfort; digestion; elimination; fluids/electrolytes; health, wellness, and illness; immunity; infection; inflammation; intracranial regulation; metabolism; mobility; nutrition; oxygenation; perfusion; perioperative care; sensory perception; sexuality; thermoregulation, and tissue integrity. These concepts are illuminated with nearly 100 exemplars covering the entire lifespan.