This book examines generic mechanisms in neurodegenerative diseases. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases including Parkinson disease, multiple sclerosis, Alzheimer's disease, spinal muscular atrophy, acute ischemic stroke, and cognitive dysfunction syndrome. The spectrum of various factors concerned with neurodegeneration, like oxidative stress, regulators, zinc, astrocytes, protein aggregation, caspases and secretase, cholesterol, oligodendrocytes, microglia, etc., have been elucidated in the light of disease progression. In addition, new approaches to therapeutic interventions have also been described. This book will serve as a substantial source of information for students, clinicians and scientists.