Autoimmune disorder is a condition that arises when the immune system of human body attacks and kills healthy body tissue by mistake. A large number of people around the globe are being affected by autoimmune disorders. These are the second most common cause of chronic illness. Due to changing lifestyles, a lot more people are being diseased by autoimmune diseases. This book discusses the need for new developments in this field to discover and formulate cures for these disorders. A proper understanding of the functioning of gene expressions and accelerating signaling channels, which is related to the autoimmune pathogenesis while being connected to the recent data for the communication of microbiota with human immune system, will give a better insight into the immune imbalance implicated in autoimmunity.